Editors have a very important role as they have responsibilities to authors as well as reviewers, readers, study subjects and publishers. They usually face many challenges to start a new scientific journal especially in some developing countries. The most often and frequent problems related to authors’, staffs, referees, editors, indexing database, social pressure, etc. In this paper a comprehensive description of all challenges and approaches are mentioned. In the beginning of publication chain, authors usually fail to comply with journal guidelines, duplicate submission, plagiarism, slicing. Then the editor encounter to poor quality reviewers and untrained editorial staff. To top all this, it is every journals wish to improve their standard as well as increasing the quality of the journal to become indexed in high quality and important databases, while importance of these database may change from time to time. The editor normally is under the pressure of this vicious cycle and has to contribute to the everyday improvement of the journal and maintaining the integrity of the scientific content. It seems that, despite all mentioned problems and expectance, editors can usually dominate all obstacles by their motivation, hope and love to the help science to be published more and more, otherwise no journal was developed specially in some developing countries.